Candidatus Mycoplasma girerdii

(Fettweis et al., 2014)

Etymology

Gr. n. mukes – fungus, Gr. neut. n. plasma – formed, N.L. neut. n. Mycoplasma – fungus form; N.L. gen. n. girerdii – of Girerd (referring to P.H. Girerd)

Taxonomy

Mycoplasmatales – Mycoplasmataceae – Mycoplasma – Candidatus Mycoplasma girerdii (not part of a cluster), separated branch (Fig. 1)

Type strain

not available, not cultivated in/on cell free media (Fig. 2, 16S rRNA gene sequence of isolate VCU_M1)

Genomes

2 completed (VCU_M1 – USA; UC_B3 – USA); 2 draft genomes (NCBI Genome deposit per 11/05/2024)

Cell morphology

coccoid – rod-shaped

Colony morphology

not cultivated on a cell free medium

Metabolism

fermentation of glucose; non-arginine-hydrolyzing, non-urea-hydrolyzing

Host

human

Habitat

vagina in adult, oropharynx in newborn by vertical transmission during delivery

Disease(s)

associated with trichomoniasis (Trichomonas vaginalis)

Pathogenicity

factors largely unknown, potential factors include two collagenases, a hemolysin, an O-sialoglycoprotein endopeptidase and a feoB-type ferrous iron transport system

Epidemiology

unknown, reported to occur in women with trichomoniasis in the USA

Diagnosis

PCR

Fig. 1. Maximum likelihood tree showing the phylogenetic position of Candidatus Mycoplasma girerdii isolate VCU_M1 close to the Pneumoniae cluster of Mycoplasmataceae based on 16S rRNA gene sequences. The sequence of Mycoplasma synoviae WVU 1853^T was used as out-group (Synoviae cluster). Numbers at nodes represent bootstrap confidence values (1000 replications). Only values > 80% are shown. Bar, number of substitutions per nucleotide position. Credits: Joachim Spergser (Vetmeduni Vienna)

>Candidatus Mycoplasma girerdii isolate VCU_M1

TCAATTTTTGAGAGTTTGATCCTGGCTCAGGATTAACGCTAGCGGTATGCCTAATACATGCAAGTCGAGCGGAGGTAGCAATACCTTAGCGGCGAACGGGTGAGTAATACGTATCTAATCTGCCCTTTAGAAAGGAACAACAGATCGAAAGATTTGCTAATACCTTATATGATATACATTCGCATGAAAGTATATTTAAAGTTGCGTTTGCAACGCTTTAGGATGAGGGTGCGGTTTATCAGATAGTTGGTGAGGTAATGGCTCACCAAGTCAATGACGAATAGCTATGCTGAGAGGTAGAATAGCCACAAGGGGACTGAGACACGGCCCCTACTCCTACGGGAGGCAGCAGTAGGGAATTTTTCACAATGGGCGAAAGCCTGATGGAGCAATACCGCGTGAATGATGAAGGTCTTCGGATTGTAAAATTCTTTTATTAGGGACGAACGGCACTAAGAGGAAATGCTTAGTGATTGACTGTACCTATTGAATAAGTAACGGCAAACTATGTGCCAGCAGCCGCGGTAATACATAGGTTACAAGCGTTATCCGGATTTACTGGGCGTAAAGCGAGCGCAGGCTGATTAACAAGTCTAGTGTGAAATGCAGTTGCTTAACAACTGTTTGCATTGGAAACTGTTAGTCTGGAGTGTGATAGGGAGTTCTGGAACTCCATATGGAGCGGTGGAATGCGTAGATATATGGAAGAACACCTGTGGCGAAAGCGAGAACTTAGGTCACAACTGACGCTTAGGCTCGAAAGTGTGGGGAGCAAATAGGATTAGATACCCTAGTAGTCCACACCGTAAACGATGGTTATTAGTTGTTGGTACGAAGTACTAGTAACGAAGCTAACGCATTAAATAACCCGCCTGGGTAGTACATTCGCAAGAATGAAACTCAAACGGAATTGACGGGGACCCGCACAAGTGGTGGAGCATGTTGTTTAATTCGACAGTACACGAAGAACCTTACCAGGGTTTGACATCCTCGGCAAAGCTATAGAAATATAGTGGAGGTTAACCGAGAGACAGGTGGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCCTATTGTTAGTTACTTTATCTAACGAGACTGCTAACGCAAGTTAGAGGAAGGTGGGGATGACGTCAAATCATCATGCCCTTTATATCCTGGGCCACAAACGTGCTACAATGGTTGGTACAAACTGTTGCCAAACTGTAAAGTGGAGCTAATCAGAAAAAACCAATCTCAGTTCGGATTGAGGGCTGAAATTCGTCCTCATGAAGTTGGAATCACTAGTAATCGCGAATCAGACATGTCGCGGTGAATGCGTTCTCGGGTCTTGTACACACCGCCCGTCAAACTATGAGAGTCGTTAATACCTAAAACCGTCCTGCTAACCGTAAGGGAGCGGATGTCTAGGGTAGGAATGATGATTGGAGTTAAGTCGTAACAAGGTACCCCTACGAGAACGTGGGGGTGGATCACCTCCTTTCTA

Fig. 2. 16S rRNA gene sequence of Candidatus Mycoplasma girerdii isolate VCU_M1(Accession number: CP007711)

Candidatus species assigned by: Fettweis, J.M., Serrano, M.G., Huang, B., Brooks, J.P., Glascock, A.L., Sheth, N.U., Vaginal Microbiome Consortium, Strauss III, J.F., Jefferson, K.K., Buck, G.A. 2014. An emerging mycoplasma associated with trichomoniasis, vaginal infection and disease. PLOS ONE 9: e110943.